1 00:00:06,840 --> 00:00:07,941 Hello my name is 2 00:00:07,941 --> 00:00:11,644 Ryan Kennedy and I'm a product manager here at Sysmex America. 3 00:00:11,911 --> 00:00:14,748 Today, I have the pleasure of introducing to you, 4 00:00:14,748 --> 00:00:17,984 Sysmex's instrument for animal testing laboratories. 5 00:00:17,984 --> 00:00:21,354 The XN-V automated hematology analyzer. 6 00:00:21,688 --> 00:00:25,125 This instrument is an animal blood cell analyzer that uses 7 00:00:25,125 --> 00:00:28,628 the same advanced technology that makes Sysmex a leader 8 00:00:28,628 --> 00:00:31,498 in the human clinical hematology laboratory market. 9 00:00:31,531 --> 00:00:34,200 In this demonstration, I'll briefly go over with you. 10 00:00:34,200 --> 00:00:36,336 The key elements of this analyzer, 11 00:00:36,336 --> 00:00:39,105 as well as some of its main operational features. 12 00:00:39,239 --> 00:00:42,709 To get started, I wanted to talk about the configurations. 13 00:00:43,009 --> 00:00:47,881 The XN-V Series also has the flexibility to accommodate any laboratory 14 00:00:47,881 --> 00:00:51,584 based on the volumes that you have in your testing facility. 15 00:00:52,185 --> 00:00:56,222 So next to me, we have what we call an XN-1000V. 16 00:00:56,656 --> 00:00:59,559 This has one CBC analyzer module. 17 00:01:00,060 --> 00:01:04,164 We also have an XN-2000V available, 18 00:01:04,164 --> 00:01:09,636 which has two analyzers side by side that gives you that co-primary design, 19 00:01:09,636 --> 00:01:14,040 which enhances your efficiency for testing of the samples in your laboratory. 20 00:01:14,040 --> 00:01:18,378 And last but definitely not least, we have an XN-3100V 21 00:01:18,445 --> 00:01:23,249 which builds off of the enhanced efficiency of that XN-2000V 22 00:01:23,450 --> 00:01:25,985 with having those two CBC analyzers, 23 00:01:26,119 --> 00:01:31,858 but with the added benefit of having our SP-50 automated slide preparation unit, 24 00:01:31,858 --> 00:01:36,463 which will make excellent quality blood smears for those necessary manual reviews. 25 00:01:36,463 --> 00:01:40,467 And to further build off that, the XN-3100V 26 00:01:40,467 --> 00:01:45,004 also has the capability to add on an optional DI-60, 27 00:01:45,004 --> 00:01:48,975 which is an automated digital cell locating and imaging device, 28 00:01:48,975 --> 00:01:52,545 which will ensure that any manual smear reviews that are performed 29 00:01:52,545 --> 00:01:56,516 are completely standardized regardless of who performs the review. 30 00:01:56,883 --> 00:02:00,520 Now, with these configurations, we also have what we call wagons. 31 00:02:00,553 --> 00:02:04,691 This is the XN-1000V on a Sysmex wagon. 32 00:02:04,858 --> 00:02:08,128 And it consolidates all the reagents used on this analyzer 33 00:02:08,128 --> 00:02:12,398 to give you that sleek design and optimization of your workflow. 34 00:02:13,032 --> 00:02:14,667 However, you can also configure 35 00:02:14,667 --> 00:02:18,705 any of the XN-V Solutions, as I mentioned, to be benchtop models. 36 00:02:18,705 --> 00:02:20,874 If you have a solution in your laboratory 37 00:02:20,874 --> 00:02:23,543 that works already for housing your reagents. 38 00:02:23,643 --> 00:02:25,945 Now let's go over to our screen here 39 00:02:26,246 --> 00:02:28,882 and I want to bring you to our sample explorer. 40 00:02:28,982 --> 00:02:31,951 This is where you will have your scientists review any samples 41 00:02:31,951 --> 00:02:36,589 that have been analyzed on the instrument and need further intervention or review. 42 00:02:37,056 --> 00:02:40,927 In this area, you can see a lot of different information about your samples. 43 00:02:41,294 --> 00:02:44,597 For example, on this furthest left hand column. 44 00:02:44,597 --> 00:02:47,934 You can see if your sample was analyzed in the whole blood mode 45 00:02:47,934 --> 00:02:50,103 or the body fluid mode. 46 00:02:50,103 --> 00:02:54,040 And then in these subsequent columns, you are shown the sample number 47 00:02:54,040 --> 00:02:58,178 as well as the species type that was selected when the sample was analyzed. 48 00:02:58,545 --> 00:03:01,614 Now, if you jump over to the other side of the screen, 49 00:03:02,282 --> 00:03:05,618 you'll see the date and time the sample was analyzed 50 00:03:05,618 --> 00:03:09,455 as well as if there was any Re-Analysis performed. 51 00:03:09,856 --> 00:03:11,925 This Re-Analysis indicates 52 00:03:11,925 --> 00:03:16,296 if the sample was electronically measured again but under different species 53 00:03:16,296 --> 00:03:20,700 gating setting than the original species that was set to the sample number. 54 00:03:21,167 --> 00:03:24,370 I'll get more into this functionality a little later in the demonstration. 55 00:03:24,370 --> 00:03:27,307 But in this ‘Sample Explorer’ area, you'll see 56 00:03:27,307 --> 00:03:29,943 an overview of information of the sample. 57 00:03:30,143 --> 00:03:32,579 However, if you want to look at the actual values 58 00:03:32,579 --> 00:03:36,683 of the particular sample, you'll either simply double-click 59 00:03:37,016 --> 00:03:40,653 on that row that you're interested in, or you can click up here 60 00:03:40,954 --> 00:03:42,455 on our ‘Browser’ icon. 61 00:03:42,455 --> 00:03:43,923 Within this ‘Browser’ area, 62 00:03:43,923 --> 00:03:47,293 you can now see all the testing that was performed on this sample. 63 00:03:47,727 --> 00:03:50,797 On this left side of the screen, you can see the full complete 64 00:03:50,797 --> 00:03:55,201 CBC enumeration as well as the Reticulocyte panel. 65 00:03:55,435 --> 00:03:59,272 Leukocyte differential and Immature Platelet Fraction information. 66 00:03:59,272 --> 00:04:03,476 In the center, you'll see any flags associated with the sample analysis. 67 00:04:03,476 --> 00:04:07,814 And finally, on the right hand side, you can see all the associated Scattergrams. 68 00:04:07,814 --> 00:04:11,618 Now, if your laboratory is interested in exporting the sample data. 69 00:04:11,818 --> 00:04:15,755 You can upload data to an LIS or graphic printer, 70 00:04:15,822 --> 00:04:20,760 or even export the data onto an external flash drive in Excel format 71 00:04:21,661 --> 00:04:23,162 with this XN-V Series 72 00:04:23,162 --> 00:04:27,133 there's a lot of customization with the species software functionality. 73 00:04:27,300 --> 00:04:30,570 Not going to go into the full details on these capabilities 74 00:04:30,570 --> 00:04:32,605 within this demonstration. 75 00:04:32,605 --> 00:04:37,310 However, I do want to show you that on this analyzer it has the ability 76 00:04:37,310 --> 00:04:41,981 to electronically re-analyze the sample that has already been aspirated. 77 00:04:42,248 --> 00:04:45,752 I refer to this as on the fly species changes. 78 00:04:46,052 --> 00:04:49,022 So this means that if you originally identified the sample 79 00:04:49,022 --> 00:04:53,459 as being from a dog, but it was really from a mouse, 80 00:04:53,459 --> 00:04:57,964 instead of needing to aspirate that sample again, you can use the ‘ReAna’ 81 00:04:57,964 --> 00:05:01,734 or Re-Analyze tool to select the correct species. 82 00:05:02,268 --> 00:05:04,370 The XN-V 83 00:05:04,604 --> 00:05:08,341 will then apply the correct gating for the new species selected 84 00:05:08,341 --> 00:05:12,512 and will allow you to add any additional comments for tracking purposes. 85 00:05:13,046 --> 00:05:16,349 Also, the original sample analysis is retained, 86 00:05:16,516 --> 00:05:19,952 so you will have both the results to ensure that you have full tracking 87 00:05:19,952 --> 00:05:23,089 and full transparency of the sample handling. 88 00:05:23,556 --> 00:05:26,726 The XN-V Series uses impedance counting and Flow 89 00:05:26,726 --> 00:05:29,729 Cytometry technology to obtain accurate results. 90 00:05:29,729 --> 00:05:33,533 The red blood cell count hematocrit and primary platelet 91 00:05:33,533 --> 00:05:36,936 count are performed in the red blood cell impedance aperture. 92 00:05:36,936 --> 00:05:40,673 This channel uses hydrodynamic focusing to ensure separation 93 00:05:40,673 --> 00:05:44,510 and consistent sizing of the cells as they pass through that aperture. 94 00:05:44,510 --> 00:05:48,481 Additionally, the flow cell on the XN-V uses a combination 95 00:05:48,481 --> 00:05:52,352 of specialized Diluents, Lysis and Fluorescent stains 96 00:05:52,352 --> 00:05:56,356 to obtain the white blood cell count and automated differential. 97 00:05:56,356 --> 00:06:00,493 This analyzer also offers a comprehensive Reticulocyte panel 98 00:06:00,493 --> 00:06:03,796 that not only provides an absolute and relative count, 99 00:06:03,996 --> 00:06:07,934 but each ‘Retic’ also includes the immature Reticulocyte Fraction 100 00:06:08,034 --> 00:06:11,003 and the Reticulocyte Hemoglobin Equivalent. 101 00:06:11,003 --> 00:06:12,939 The XN-V Series also uses 102 00:06:12,939 --> 00:06:16,809 a fluorescent stain in the flow cell that is specific to platelets. 103 00:06:16,809 --> 00:06:20,179 This fluorescent platelet parameter serves as a secondary platelet count 104 00:06:20,179 --> 00:06:21,581 in the Whole Blood mode 105 00:06:21,581 --> 00:06:26,686 when the impedance count is either flagged or the sample has thrombocytopenia. 106 00:06:27,220 --> 00:06:28,321 Lastly, 107 00:06:28,321 --> 00:06:31,491 the specialized stain cartridges are located 108 00:06:31,491 --> 00:06:36,863 under the lid of the analyzer and use radio frequency IDs 109 00:06:37,397 --> 00:06:40,199 for recording lot information and cycle count. 110 00:06:40,767 --> 00:06:43,736 When performing quality control on these analyzes. 111 00:06:43,870 --> 00:06:48,608 There are three levels of QC for the whole blood and Reticulocyte parameters, 112 00:06:48,941 --> 00:06:52,311 that give an excellent indication that your analyzer is providing quality 113 00:06:52,311 --> 00:06:56,115 results across the entire measurement range capabilities. 114 00:06:56,616 --> 00:06:59,018 In case your facility is interested in performing 115 00:06:59,018 --> 00:07:02,688 body fluid analysis on your animal testing population. 116 00:07:02,855 --> 00:07:07,093 The XN-V also has a separate body fluid QC material available 117 00:07:07,293 --> 00:07:09,962 on the XN-V series instruments 118 00:07:09,962 --> 00:07:14,300 both auto-loader and manual sample analysis capabilities are offered 119 00:07:14,534 --> 00:07:17,970 to switch over into that manual aspiration measurement mode 120 00:07:17,970 --> 00:07:20,973 you simply just need to press this button 121 00:07:21,107 --> 00:07:23,309 on the front of your analyzer. 122 00:07:23,309 --> 00:07:26,345 This triggers the manual holder assembly to eject. 123 00:07:26,612 --> 00:07:30,283 And then if we look over here on the screen, you'll see that you have 124 00:07:30,283 --> 00:07:35,021 a lot of different options available to you in your manual analysis holder. 125 00:07:35,021 --> 00:07:38,224 You can also see that there are two holders available. 126 00:07:38,257 --> 00:07:43,129 This back holder here is for if you're going to process any micro 127 00:07:43,129 --> 00:07:48,000 trainer samples in your laboratory and in the front holder here, 128 00:07:48,000 --> 00:07:52,104 this is going to be used for our standard sized tubes 129 00:07:52,104 --> 00:07:54,974 or even those raised bottom 130 00:07:54,974 --> 00:07:58,945 tubes or RBT tubes. For measurement mode selection 131 00:07:58,945 --> 00:08:02,281 on your XN-V Series Automated Hematology Analyzer. 132 00:08:02,448 --> 00:08:05,418 It's again simply done with the touch of a button. 133 00:08:05,551 --> 00:08:08,888 You will see that you have multiple options available to you 134 00:08:08,888 --> 00:08:10,490 for your mode selection. 135 00:08:11,491 --> 00:08:15,294 You have ‘Whole Blood’ mode, ‘Low WBC’ mode, 136 00:08:15,394 --> 00:08:20,600 ‘Pre-Dilution’ mode, ‘Low Aspiration’ mode and ‘Body Fluid’ mode. 137 00:08:20,766 --> 00:08:25,404 Now if your laboratory needs to process more than one sample at a time, 138 00:08:25,538 --> 00:08:29,842 you're going to want to use what we call an ‘Auto Loader Rack’ These racks 139 00:08:29,842 --> 00:08:34,046 have ten positions and you can place your samples anywhere 140 00:08:34,280 --> 00:08:36,182 in these positions. 141 00:08:37,049 --> 00:08:39,218 And the analyzer is going to know where 142 00:08:39,218 --> 00:08:42,321 that sample is and perform aspiration. 143 00:08:42,421 --> 00:08:47,293 With the XN-V Series, you're also able to configure your solution to download 144 00:08:47,293 --> 00:08:51,030 demographic information so that your analyzer knows 145 00:08:51,030 --> 00:08:54,667 exactly which species gating to use on each sample. 146 00:08:54,767 --> 00:08:58,871 So there's no need to batch your specific species types together. 147 00:08:59,005 --> 00:09:02,608 Again, expanding on that flexibility of this analyzer, 148 00:09:02,942 --> 00:09:06,879 since I talked a lot about the types of tubes you can use on your system 149 00:09:07,079 --> 00:09:09,582 and the flexibility within the manual mode, 150 00:09:09,749 --> 00:09:13,052 I'll share a few slides to show all the different measurement modes 151 00:09:13,052 --> 00:09:15,621 and the required volumes. 152 00:09:19,892 --> 00:09:23,229 Now let's talk about how easy it is to perform routine 153 00:09:23,229 --> 00:09:26,198 maintenance on your XN-V Series analyzers. 154 00:09:26,198 --> 00:09:29,135 For daily cleaning of your analyzer. 155 00:09:29,502 --> 00:09:32,905 You’re going to use what we call CellClean Auto. 156 00:09:33,239 --> 00:09:35,508 This is a premix pre labeled cleaning 157 00:09:35,508 --> 00:09:41,080 agent to be used with your XN-V Solution when performing maintenance on your XN-V 158 00:09:41,080 --> 00:09:43,983 All you have to do is run this one tube 159 00:09:43,983 --> 00:09:47,019 of cleaning solution through your analyzer and that's it. 160 00:09:47,887 --> 00:09:50,856 The cleaning solution will run through the fluidics 161 00:09:51,057 --> 00:09:55,361 of the analyzer and then perform a shutdown of the computer. 162 00:09:55,361 --> 00:09:59,298 To perform this cleaning and shutdown, you have two different options. 163 00:09:59,298 --> 00:10:03,669 You can either run the CellClean Auto through the manual mode demonstrated here 164 00:10:03,903 --> 00:10:07,373 or you can run it through an auto loader rack as well. 165 00:10:07,406 --> 00:10:11,978 Just note that if you have one of our larger XN-V Series 166 00:10:11,978 --> 00:10:15,815 solutions, you need to have one tube of CellClean 167 00:10:15,815 --> 00:10:18,884 per analyzer or SP-50. 168 00:10:19,251 --> 00:10:22,021 Regardless of which mode you use on your analyzer, 169 00:10:22,021 --> 00:10:25,992 though, the analyzer will read the barcode and sense that it's time 170 00:10:25,992 --> 00:10:27,760 to perform maintenance. 171 00:10:27,893 --> 00:10:32,331 For those laboratories that don't operate daily, you will only need to perform 172 00:10:32,331 --> 00:10:36,135 this maintenance once a day when your analyzer is being used. 173 00:10:36,302 --> 00:10:42,842 Also, if your lab chooses either the XN-2000V or the XN-3100V solutions, 174 00:10:42,842 --> 00:10:45,544 you'll have additional flexibility to perform maintenance 175 00:10:45,544 --> 00:10:49,181 on one analyzer at a time if that's desired for you. 176 00:10:49,315 --> 00:10:52,818 So in summary, in addition to our innovative technology 177 00:10:52,818 --> 00:10:56,288 and vastly customizable solution, you will also enjoy 178 00:10:56,288 --> 00:11:00,092 the outstanding service and support that makes Sysmex number one 179 00:11:00,092 --> 00:11:04,797 in Service, Customer Satisfaction and Analyzer Performance. 180 00:11:04,797 --> 00:11:09,368 As one of the leaders in the Hematology Laboratory Diagnostics, Sysmex remains 181 00:11:09,368 --> 00:11:13,873 committed to supporting veterinary testing facilities, your unique needs 182 00:11:13,873 --> 00:11:18,577 and the vital role that you play in the health care and pharmaceutical industries.