Immature Granulocyte Fact Sheet

Immature Granulocyte Fact Sheet

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What are Immature Granulocytes?

Immature Granulocytes (IG) are early precursors of granulocytic white blood cells, including neutrophils, eosinophils, and basophils. Under normal conditions, these immature cells mature within the bone marrow and are not typically present in peripheral blood. Their appearance in the bloodstream can signal various clinical conditions such as infections, inflammation, or bone marrow disorders.

Stages of Granulocyte Maturation

Granulocyte development, known as granulopoiesis, occurs in the bone marrow through several stages:

  1. Myeloblast
  2. Promyelocyte
  3. Myelocyte
  4. Metamyelocyte
  5. Band cell or “band”
  6. Segmented granulocyte or “seg”

Immature Granulocytes (IG) specifically include:

  • Promyelocytes
  • Myelocytes
  • Metamyelocytes

These stages are considered immature due to their incomplete development and lack of full functional capabilities compared to mature granulocytes (bands & segs).

Sysmex Hematology Analyzers and IG Measurement

Sysmex Hematology Analyzers are advanced diagnostic tools capable of detecting and quantifying IG in peripheral blood samples.

  • Detection Point: These analyzers measure IG when immature granulocytes are prematurely released into peripheral circulation from the bone marrow.
  • Cell Types Detected: Promyelocytes, myelocytes and metamyelocytes are included in the automated IG count.
  • Technology Used: Utilizing fluorescence flow cytometry and specialized reagents, many Sysmex analyzers provide accurate IG counts as part of the standard 6-part differential.


Advantages of Sysmex IG Measurement

  • Automated Analysis: Delivers rapid and reliable results, reducing reliance on manual microscopic examination.
  • High Sensitivity: Detects low levels of IG that may be overlooked in manual counts.
  • Standardization: Ensures consistent results across different laboratories and operators.
  • Comprehensive Reporting: Provides both percentage and absolute counts of IG, facilitating precise clinical assessment.

Measuring Immature Granulocytes (IG) using Sysmex Hematology Analyzers is pivotal in modern diagnostics. By detecting early stages of granulocyte maturation in peripheral blood, healthcare professionals can more effectively identify and monitor various clinical conditions. The integration of advanced technology in Sysmex analyzers enhances diagnostic capabilities, contributing to improved patient care and management

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