Laboratory Diagnosis of Hemoglobinopathies – Bonus Case Studies

3/19/2012
12:00 PM to 1:00PM (Americas) Central Time (US & Canada)

Edward C.C. Wong, M.D. Director, Hematology Associate Director, Transfusion Medicine Medical Director, Peripheral Blood Stem Cell Collection (FACT) Center for Cancer and Blood Disorders Division of Laboratory Medicine Sheikh Zayed Campus for Advanced Children’s Medicine Children’s National Medical Center Associate Professor of Pediatrics and Pathology George Washington School of Medicine and Health Sciences Washington, D.C.

This bonus session is a continuation of the first session – laboratory diagnosis of hemoglobinopathies. This session will tackle 2 more difficult case studies that explore methods for the evaluation hemoglobinopathies, specifically variant hemoglobins. These approaches will highlight the utility of peripheral smear review, RBC and reticulocyte indices, use of capillary zone and gel electrophoresis for hemoglobinopathy evaluation. In addition, the use of HPLC and DNA techniques will be discussed.

Objectives:

  • Understand how RBC and reticulocyte indices can be used to distinguish between thalassemia and iron deficiency
  • Understand the strengths and weaknesses of various diagnostic tests for hemoglobinopathies
  • Determine optimal testing strategies for the evaluation of hemoglobinopathies
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