Laboratory Diagnosis of Hemoglobinopathies – Bonus Case Studies
12:00 PM to 1:00PM (Americas) Central Time (US & Canada)
Edward C.C. Wong, M.D.
Associate Director, Transfusion Medicine
Medical Director, Peripheral Blood Stem Cell Collection (FACT)
Center for Cancer and Blood Disorders
Division of Laboratory Medicine
Sheikh Zayed Campus for Advanced Children’s Medicine
Children’s National Medical Center
Associate Professor of Pediatrics and Pathology
George Washington School of Medicine and Health Sciences
This bonus session is a continuation of the first session – laboratory diagnosis of hemoglobinopathies. This session will tackle 2 more difficult case studies that explore methods for the evaluation hemoglobinopathies, specifically variant hemoglobins. These approaches will highlight the utility of peripheral smear review, RBC and reticulocyte indices, use of capillary zone and gel electrophoresis for hemoglobinopathy evaluation. In addition, the use of HPLC and DNA techniques will be discussed.
Understand how RBC and reticulocyte indices can be used to distinguish between thalassemia and iron deficiency
Understand the strengths and weaknesses of various diagnostic tests for hemoglobinopathies
Determine optimal testing strategies for the evaluation of hemoglobinopathies