XN-Series™ with Blood Bank Mode - Perform quality control of blood products using one hematology analyzer

XN-Series™ with Blood Bank Mode - Perform quality control of blood products using one hematology analyzer

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Blood component safety is key in transfusion medicine and blood product manufacturing. Therefore, high standards during the whole process from donor qualification to quality monitoring of the products are required. Tantamount to blood product safety is residual cell enumeration, but many hematology analyzers aren’t able to reach the lower limit of quantification required for this. The XN-1000™ and XN-2000™ with Blood Bank Mode by Sysmex offers a holistic solution that covers donors, patients and blood components, giving laboratories confidence in the quality of processed blood products.

The XN-Series analyzer with Blood Bank Mode is FDA-cleared to provide:

  • Fully automated analysis for standardized workflows
  • A single platform for multiple hematological parameters and blood product QC, including residual WBC counts
  • Time-efficient routine analysis of red blood cell, platelet and plasma packs

 

Blood component safety

The Blood Bank Mode on the XN-1000 and XN-2000 analyzers

  • Measures residual white and red blood cells in blood components
  • Determines RBC and platelet concentrations in blood products

 

Patient care

The XN-Series analyzers by Sysmex provide advanced clinical parameters such as the Reticulocyte Hemoglobin Equivalent (RET-He) and Immature Platelet Fraction for evaluating cell line data specific to donor blood samples (available in Whole Blood Mode only).

Your benefits in daily routine

Say good-bye to current methods which are often time-consuming, costly and dependent on the individual skills of the staff. The XN-Series with Blood Bank Mode offers product testing laboratories these operational benefits:

  • No manual preparation needed, simple to operate for everyone in the laboratory.
  • Saves time by analyzing various key parameters using one instrument.
  • Accurately and reproducibly identifies blood components in which leukodepletion has failed.
  • Provides a consistent, standardized and automated assessment of blood product quality to promote patient safety.

 

Blood components and measuring profiles

The Blood Bank mode offers the analysis of blood components with four different selectable profiles – two profiles for red blood cell concentrates and two profiles for platelet concentrates. Plasma packs can be measured in the profile for platelet concentrates and residual cells.

 

Technological requirements

The XN-1000 and XN-2000 hematology analyzers are available with the Blood Bank Mode offering the potential to automate, simplify and rationalize the transfusion medicine and blood manufacturing workflow. The XN analyzer requires the RET and PLT-F applications and a Blood Bank mode license to perform this testing.

 

Improving your workflow

International guidelines require blood component safety, making residual cell enumeration a crucial component of product QC. Current methods for the enumeration of rWBC are either manual methods such as visual inspection and chamber counting or semi-automated methods such as flow cytometry or fluorescent image analysis. Each of these methods requires manual sample preparation and skilled staff, resulting in potential procedural errors.

Workflow improvements with the Blood Bank mode:

  • Standardized methods for more consistent results
  • Easy to operate for all lab staff
  • Consolidated analysis of multiple hematologic parameters on one analyzer
  • No additional tube sampling
  • Fully automated measurement in sampler mode

 

Measurement mode

Manual mode and automated sampler mode

 

Aspirated volume

  • RBC pack: 150 μL
  • PLT pack: 205 μL

 

Anticoagulants

  • Red blood cell concentrates with anticoagulants: CPD, CP2D, ACD-A, CPDA-1
  • Platelet concentrates with anticoagulants: CPD, ACD-A

 

Time per single measurement:

  • RBC profile with residual cell measurement: less than 2 minutes
  • PLT profile with residual cell measurement: approx. 3 minutes

 

Performance specifications for rWBC

  • Limit of blank (LoB): 0.0001 x103/μL
  • Limit of detection (LoD): 0.0004 x103/μL
  • Limit of quantification (LoQ): 0.0004 x103/μL

 

Sample tube types:

  • We recommend using the same EDTA tubes for the Blood Bank mode as used for whole blood analysis.

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